Activity of Phenolic Compounds in Figs (Ficus carica L.) as Antihyperlipidemic through in Silico Study

<p>Figs (Ficus carica L.) belongs to family Moraceae which contains a lot of phenolic compounds that have an antihyperlipidemic effect. However, the figs not been intensively studied. The purpose this study was determine activity in as inhibiting work HMG-CoA reductase enzyme. This research uses experimental technique with silico method. in-silico method performed predict physicochemical, pharmacokinetic, toxicity, and molecular docking properties by comparing Pravastatin receptor. Rutaretin, Pimpinellin dan Seselin has highest affinity values, met toxicity parameters compared Psoralen, 8-Methoxypsoralen, Angelicin, Bergapten control compounds. presence binding enzyme able inhibit amino acid residues Cys526, Gln814, Ile536, Leu811, Ile762, Pro813, Ala763, Ala556, Val538, Pro535, Tyr533, Met534, Gly765, Tyr517, Val522, Cys527. These results suggest Pimpinellin, could be on action enzyme.</p>